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Short tandem repeat sequences in the <Emphasis Type="Italic">Mycoplasma genitalium</Emphasis>genome and their use in a multilocus genotyping system |
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| Authors: | Liang Ma Stephanie Taylor Jørgen S Jensen Leann Myers Rebecca Lillis David H Martin |
| Institution: | (1) Section of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA;(2) Mycoplasma Laboratory, Statens Serum Institut, DK-2300, Copenhagen S, Denmark;(3) Department of Biostatistics, Tulane University, New Orleans, LA 70112, USA |
| Abstract: | BackgroundSeveral methods have been reported for strain typing of Mycoplasma genitalium. The value of these methods has never been comparatively assessed. The aims of this study were: 1) to identify new potential genetic markers based on an analysis of short tandem repeat (STR) sequences in the published M. genitalium genome sequence; 2) to apply previously and newly identified markers to a panel of clinical strains in order to determine the optimal combination for an efficient multi-locus genotyping system; 3) to further confirm sexual transmission of M. genitalium using the newly developed system. |
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