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Expression of GABA transaminase immunoreactivity in interneurons of the rat neostriatum |
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| Authors: | Yung K K Kwok K H Gao Z G Choi S Y Kwok F S |
| Institution: | 1Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China 2Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China 3Department of Genetic Engineering, Hallym University, Chunchon, South Korea 4Department of Applied Science, Technical College Chai Wan, Vocational Training Council, Chai Wan, Hong Kong, China |
| Abstract: | Immunoreactivity for γ-aminobutyric acid transaminase (GABA-T), a degradation enzyme for GABA, was localized by immunocytochemistry in the rat neostriatum and the globus pallidus using a monoclonal antibody. Immunoreactivity for GABA-T was found primarily in interneurons and in the neuropilar elements in the neostriatum. Many of GABA-T-immunoreactive neurons were found to display parvalbumin immunoreactivity. This indicates many of the GABA-T-immunoreactive neurons are striatal GABAergic interneurons. Occasionally, GABA-T-immunoreactive glial cells were found. In the globus pallidus, many pallidal neurons also displayed GABA-T immunoreactivity and many of the immunoreactive neurons were seen to express parvalbumin immunoreactivity. Immunoreactivity for GABA-T was also detected in the neuropil of the globus pallidus. The present results indicate the GABAergic interneurons in the neostriatum and a subpopulation of pallidal neurons play an important role in metabolic degradation of GABA in the basal ganglia. |
| Keywords: | Immunocytochemistry Avidin–biotin–peroxidase reaction Immunofluorescence Light mircoscopy Basal ganglia |
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