Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide |
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| Authors: | H J Showell I G Otterness A Marfat E J Corey |
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| Affiliation: | 1. Department of Immunology & Infectious Disease, Pfizer Central Research, Groton, CT 06340 USA;2. Department of Chemistry, Harvard University, Cambridge, MA 02138 USA. |
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| Abstract: | Leukotriene B4 (LTB4) is a potent mediator of pro-inflammatory responses including neutrophil degranulation. Leukotriene B4 dimethylamide has been synthesized and shown to inhibit neutrophil degranulation induced by LTB4. The inhibition required time to develop (～60 secs), and had a KD of circa 2 × 10?7M, and occurred at concentrations where LTB4 dimethylamide had negligible agonist activity. |
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