Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches |
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Authors: | Ruth Elena Soria-Guerra Leticia Moreno-Fierros Sergio Rosales-Mendoza |
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Institution: | (1) Laboratorio de biofarmac?uticos recombinantes, Facultad de Ciencias Qu?micas, Universidad Aut?noma de San Luis Potos?, Av. Dr. Manuel Nava 6, 78210 San Luis Potosi, SLP, Mexico;(2) Inmunidad en Mucosas, UBIMED, FES-Iztacala, Universidad Nacional Aut?noma de M?xico, Avenida de los Barrios 1, 54090 Tlalnepantla, Mexico; |
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Abstract: | Genetic engineering revolutionized the concept of traditional vaccines since subunit vaccines became reality. Additionally,
over the past two decades plant-derived antigens have been studied as potential vaccines with several advantages, including
low cost and convenient administration. More specifically, genetic fusions allowed the expression of fusion proteins carrying
two or more components with the aim to elicit immune responses against different targets, including antigens from distinct
pathogens or strains. This review aims to provide an update in the field of the production of plant-based vaccine, focusing
on those approaches based on the production of chimeric proteins comprising antigens from human pathogens, emphasizing the
case of cholera toxin/E. coli enterotoxin fusions, chimeric viruses like particles approaches as well as the possible use of adjuvant-producing plants
as expression hosts. Challenges for the near future in this field are also discussed. |
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