Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats |
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Authors: | Hua-Pin Wang Ching-Wen Liu Hsueh-Wen Chang Jen-Wei Tsai Ya-Zhu Sung Li-Ching Chang |
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Affiliation: | 1. Division of Urology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan 2. School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 3. Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan 4. Department of Pathology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan 5. Department of Occupational Therapy, I-Shou University, Kaohsiung, Taiwan
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Abstract: | Cordyceps sinensis (CS) is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health. This study investigated the protective effects of CS in rats post-renal ischemia–reperfusion (I/R) sequence by analyzing the influence on stromal cell-derived factor-1α (SDF-1α and chemokine (C-X-C motif) receptor 4 (CXCR4) expressions and senescence during recovery. Chemokine SDF-1 [now called chemokine C-X-C motif ligand 12 (CXCL12)] and its receptor CXCR4 are crucial in kidney repair after ischemic acute renal failure. CS treatment significantly alleviated I/R-induced renal damage assessed by creatinine levels (p < 0.05) and abated renal tubular damages assessed by periodic acid-Schiff with diastase (PASD) staining. CS induced early SDF-1α expression and increased CXCR4 expression 1–6 h post-reperfusion. Histology studies have revealed that CS induced SDF-1α in squamous cells of Bowman’s capsule, mesangial cells, distal convoluted tubules (DCT), and proximal convoluted tubules (PCT). CS also improved renal repair in I/R-induced injury by increasing Ki-67 staining. I/R induced renal senescence after 3 and 6 h of reperfusion. However, CS alleviated I/R-induced senescence at early stage (1 and 3 h). We conclude that CS protects against I/R injury via the SDF-1/CXCR4-signaling axis and alleviates senescence. |
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