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Spin state studies on cytochrome P-450 in liver microsomes from obese and diabetic animals |
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| Authors: | E Rouer M Delaforge F Rocchiccioli G G Gibson J P Leroux |
| Institution: | 1. Laboratoire de Biochimie, INSERM U 75, 156, rue de Vaugirard, 75730 Paris Cedex 15, France;2. Laboratoire de Chimie de l''E.N.S. UA 400, 24, rue Lhomond, 75231 Paris Cedex 05, France;3. Department of Biochemistry, Division of Pharmacology and Toxicology, University of Surrey, Guildford, Surrey GU2 5XH, England;1. Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan;2. Biosignal Research Center, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan |
| Abstract: | The spin state of liver microsomal cytochrome P-450 from obese mice and streptozotocin-diabetic mice and rats has been studied both by the temperature and the type I substrates-induced spectral changes. The high spin cytochrome P-450 is significantly decreased in these animals. Moreover absolute spectra indicate that low spin cytochrome P-450 is stabilized in streptozotocin induced-diabetic animals. Thus the physiopathological state may modify the in vivo spin state of cytochrome P-450 and modifications of the microsomal fatty acid composition might contribute to these changes. |
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