Alu elements within human mRNAs are probable microRNA targets |
| |
Authors: | Smalheiser Neil R Torvik Vetle I |
| |
Institution: | University of Illinois-Chicago, UIC Psychiatric Institute MC912, 1601 W. Taylor Street, Chicago, IL 60612, USA. neils@uic.edu |
| |
Abstract: | Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typical short-seed complementarity with a specific site within Alu elements that is highly conserved within 3' untranslated regions of human mRNAs. The results suggest that at least some Alu elements within human mRNAs serve as microRNA targets. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|