Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage |
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Authors: | Susana C Rosa Juliana Gon?alves Fernando Judas Ali Mobasheri Celeste Lopes Alexandrina F Mendes |
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Affiliation: | (1) Center for Neurosciences and Cell Biology, and Faculty of Pharmacy, University of Coimbra, 3004-517 Coimbra, Portugal;(2) Orthopaedics Department, University of Coimbra, Avenida Bissaya Barreto, Bloco de Celas, 3004-075 Coimbra, Portugal;(3) Division of Veterinary Medicine, Sutton Bonington Campus, School of Veterinary Science and Medicine, University of Nottingham, LE12 5RD Sutton Bonington, UK |
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Abstract: | Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intracellular accumulation of glucose. The aim of this study was to compare the ability of normal and OA chondrocytes to regulate their glucose transport capacity in conditions of insufficient or excessive extracellular glucose and to identify the mechanisms involved and eventual deleterious consequences, namely the production of reactive oxygen species (ROS). |
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