A strategy for enrichment of claudins based on their affinity to Clostridium perfringens enterotoxin |
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| Authors: | D?rte Lohrberg Eberhard Krause Michael Schümann J?rg Piontek Lars Winkler Ingolf E Blasig Reiner F Haseloff |
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| Affiliation: | (1) Leibniz-Institut f?r Molekulare Pharmakologie (FMP), Robert-R?ssle-Str. 10, D-13125 Berlin, Germany |
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| Abstract: | Background Claudins, a family of protein localized in tight junctions, are essential for the control of paracellular permeation in epithelia and endothelia. The interaction of several claudins with Clostridium perfringens enterotoxin (CPE) has been exploited for an affinity-based enrichment of CPE-binding claudins from lysates of normal rat cholangiocytes. |
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