Glial fibrillary acidic protein and desmin in salivary neoplasms |
| |
Authors: | Hans Gustafsson Ismo Virtanen Lars-Eric Thornell |
| |
Institution: | 1. Department of Otorhinolaryngology, Head and Neck Surgery, University of Ume?, S-90185, Ume?, Sweden 2. Department of Anatomy, University of Helsinki, Helsinki, Finland
|
| |
Abstract: | The presence of intermediate filament proteins (IFP) in normal salivary gland tissue and in a number of salivary gland neoplasms
has been investigated by immunohistochemical techniques on frozen sections. Cytokeratins (CKs) were seen in almost all normal
epithelial cells. In the parotid gland and in palatal gland tissue, a co-expression of cytokeratin and glial fibrillary acidic
protein (GFAP) was seen in some myoepithelial cells, but this was not apparent in the submandibular gland. In some pleomorphic
adenomas, carcinomas in pleomorphic adenomas, one mucoepidermoid carcinoma, one mucus-producing adenopapillary carcinoma and
one adenoid cystic carcinoma, cells expressing three different IFP classes were found (CKs, vimentin, GFAP). These cells were
most often situated peripherally in the tumour cords or ducts. The cytokeratin pattern in these cells, as revealed by mAbs
PKK1-3, was similar to that in normal myoepithelial cells. Furthermore, reactivity for a fourth class of IFP, desmin, could
be seen in this cell type in two carcinomas in pleomorphic adenomas, and also in a few cells in a pleomorphic adenoma and
an adenoid cystic carcinoma. Thus the pattern of IFP expression in salivary gland neoplasms, is very complex, and cannot always
be related to the normal tissue. |
| |
Keywords: | Intermediate filament proteins Glial fibrillary acidic protein Desmin Salivary gland Neoplasms |
本文献已被 SpringerLink 等数据库收录! |
|