The Expression Level and Prognostic Value of Y-Box Binding Protein-1 in Rectal Cancer |
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| Authors: | Yu Zhang Ping-Wu Zhao Gang Feng Gang Xie An-Qun Wang Yong-Hong Yang Dong Wang Xiao-Bo Du |
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| Affiliation: | 1. Department of Oncology, MianYang Central Hospital, MianYang, People’s Republic of China.; 2. Department of Surgery, LuZhou Medical College, LuZhou, People’s Republic of China.; 3. Department of Surgery, MianYang Central Hospital, MianYang, People’s Republic of China.; 4. Department of Pathology, MianYang Central Hospital, MianYang, People’s Republic of China.; Sapporo Medical University, JAPAN, |
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| Abstract: | The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer. |
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