In vitro growth inhibition of human intestinal bacteria by sarcotoxin IA, an insect bactericidal peptide |
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Authors: | Ichiro Mitsuhara Yuki Nakajima Shunji Natori Tomotari Mitsuoka Yuko Ohashi |
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Institution: | (1) National Institute of Agrobiological Resources, 2-1-2 Kannondai, Tsukuba City, Ibaraki, 305-8602, Japan;(2) Institute Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, 351-0198, Japan;(3) Department of Veterinary of Public Health, and Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8657, Japan |
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Abstract: | Sacotoxin IA, an anti-microbial peptide of insects, inhibited the growth of harmful human intestinal bacteria such as Escherichia coli, Clostridium
ramosum and Clostridium paraputrificum, in vitro. Interestingly, E. coli O157 which is well-known to cause food poisoning, was most sensitive to the peptide among the bacteria tested. The peptide, however, did not affect the growth of Bifidobacterium adolescentis, Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis, Bacteroides thetaiotamicron, Bacteroides uniformis and Bacteroides ovatuss which are abundant in the intestines of healthy people. The evidence suggests that sarcotoxin IA could change the composition of the intestinal flora to improve human health. |
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Keywords: | anti-bacterial peptide food poisoning intestinal flora sarcotoxin IA transgenic plant |
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