糖尿病患者人巨细胞病毒感染的抗体检测分析

目的 :了解人巨细胞病毒 (HCMV)感染与糖尿病的关系。方法 :运用捕获 EL ISA、间接 EL ISA对 516例糖尿病患者及 14 8例健康正常人 HCMV-Ig M、HCMV-Ig G进行检测 ,并对比分析 HCMV感染状态 ,根据糖尿病患者的初发年龄和病程的不同进行了分组探讨。结果 :糖尿病患者 HCMV-Ig M、HCMV-Ig G抗体阳性率明显高于对照组 (P<0 .0 1) ,始发病年龄越小及病程越短的糖尿病病人 HCMV-Ig M抗体阳性率明显升高 ;年龄较大及病程较长的糖尿病人 HCMV-Ig G检出率较高。结论 :年龄小或病程短的糖尿病人以原发性 HCMV感染为主 ,HCMV感染在糖尿病的发病机制中起一定的作用

STUDY ON THE DETECTION AND ANALYSIS OF HUMAN CYTOMEGALOVIRUS ANTIBODIES IN PATIENT WITH DIABETES MELLITUS

Objective:To understand the relationsh ip between human cytomegalovirus infection and diabetes mellitus.Methods: By capturing-ELISA and indirect-ELISA,we detected the level of HCMV-I gM and HCMV-IgG in 516 diabetes mellitus patients and 148 healthy.516 diabetes mellitus patients were devided into 5 and 5 groups according to the courses of disease and age of disease onsets respectively.Results:Positive rates of HCMV-IgM and HCMV-IgG was significantly higher in diabetes mellitus patients than that of control group(P<0 01).Positive rates of HCMV-IgM was sig nificantly higher in younger patients recently suffering from diabetes mellitus. Conclusi on:Results showed that HCMV infection was important in the pathogenesis of diabetes mellitus and primary HCMV infection rates was signifcantly higher i n younger patients and /or patients suffering from diabetes mellitus.