Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells |
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| Authors: | E N Fish K Banerjee N Stebbing |
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| Institution: | 1. Division of Infectious Diseases Research Institute The Hospital for Sick Children 555 University Avenue, Toronto, Ont. M5G 1X8 Canada;2. Applied Molecular Genetics, Inc. 1900 Oak Terrace Lane, Thousand Oaks, Ca. 91320 USA |
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| Abstract: | The antigrowth effects of 5 different cloned human leukocyte IFN subtypes (IFN-alpha A, B, C, D, F) and 2 molecular hybrids between them (IFN-alpha AD(Bg1II) and IFN-alpha DA(Bg1II)) were examined on 6 different human cell lines. The results indicate that the interferons sort into two distinct groups: IFN-alpha B, C and F showed comparable antiproliferative activity which was greater than that of IFN-alpha A, D, AD(Bg1II) and DA(Bg1II). The interferons could also be assigned to one of two groups on the basis of their antiviral activity. IFN-alpha A, D and AD(Bg1II) were observed to be more protective than IFN-alpha B, C and F against HSV-2 and EMCV infections, i.e. the relative antiviral efficacies of the cloned IFN subtypes were the reverse of their antiproliferative activities. |
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| Keywords: | U/ml international standard units/ml WISH human amnion cells MDBK bovine kidney cells HSV-2 herpes simplex virus type 2 EMCV encephalomyocarditis virus |
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