High-frequency stimuli preferentially release large dense-core vesicles located in the proximity of nonspecialized zones of the presynaptic membrane in sympathetic ganglia |
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| Authors: | Cifuentes F Montoya M Morales M A |
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| Affiliation: | Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México Circuito Escolar s/número, Cd. Universitaria, México, D F. 04510, México. fcifuent@biomedicas.unam.mx |
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| Abstract: | We characterized the effect of a brief high-frequency stimulus on the number, distribution, and optical density of large dense-core vesicles (LDCVs) in the nerve terminals of the rat superior cervical ganglia. From 4.21+/-0.37 LDCVs/bouton detected in control nerve terminals, a stimulus of 40 Hz for 1 min released 41% of LDCVs, decreasing their number to 2.48+/-0.14 LDCVs/bouton (p=0.0009). In control ganglia, most dense vesicles were located close to the plasma membrane (at
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| Keywords: | synaptic boutons ultrastructure dense vesicles exocytosis |
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