Gastric erosions following sympathetic denervation in the maternally deprived rat. |
| |
Authors: | M Melinek S H Ackerman N S Sharpless M A Hofer H Weiner |
| |
Institution: | Department of Pharmacology Odense University J.B. Winsløws Vej 19 DK-5000 Odense C, Denmark |
| |
Abstract: | The adenosine triphosphate (ATP) content of rat mast cells was studied during and after histamine release induced by compound 48/80. The almost identical time course of ATP decrease from mast cells treated with either glycolytic or respiratory inhibitors seems to indicate that the ATP depletion was largely related to the histamine release process and not to an uncoupling of the oxidative phosphorylation. These results support the view that histamine release induced by compound 48/80 is an energy-requiring process. The ATP content of the cells was not, however, restored within the two hours of observation. The cause of the prolonged decrease in the ATP level has been discussed. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |