A facile solid phase synthesis of tetramic acid |
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| Authors: | Liu Zhanxiang Ruan Xiuxiu Huang Xian |
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| Affiliation: | Department of Chemistry, Zhejiang University, Campus Xixi, Hangzhou, 310028, People's Republic of China. |
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| Abstract: | The condensation of N-acylated amino acids with polymer-supported cyclic malonic acid ester was carried out in the presence of DCC/DMAP. The cyclisation of the intermediate resin, by heating in an organic solvent, gave the N-protected tetramic acid derivatives in good yields and high purity. |
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