血清胱抑素C和尿微量白蛋白在慢性肾小球肾炎早期肾功能损害评估中的意义

目的:探讨血清胱抑素C和尿微量白蛋白在慢性肾小球肾炎早期肾功能损害评估中的意义。方法:选取2010年9月至2013年7月我院收治的86名慢性肾小球肾炎患者,设为观察组。另选取同期在我院体检的年龄、性别等资料与之匹配的66名健康者设为对照组。分别对患者的CysC以及mALB的含量进行测定,并进行统计分析。结果:观察组和对照组的Cys C含量分别为(2.68±1.19)mg/L、(0.83±1.04)mg/L,观察组明显高与对照组;mALB的含量观察组为(38.16±4.25)mg/L,相比于对照组的(6.87±3.93)mg/L明显升高;Cys C及mALB阳性指标的检出率分别为75.58%、76.74%,而Cys C与mALB进行联合检测,检出率为91.86%,相比于单指标的检出率明显提高。差异具有统计学意义(P0.05)。通过对慢性肾小球肾炎患者的两项指标进行相关性分析,发现血清Cys C和尿mALB的含量呈显著的正相关(r=0.941,P0.05)。结论:将CysC与mALB相结合检测用以对慢性肾小球肾炎患者早期肾功能损害进行评估,检出率和敏感性均明显高于单指标检测。

SerumCystatin C and Urinary Albumin in Patients with ChronicGlomerulonephritis Early Renal Damage Assessment of the Significance

Objective： To investigate serum cystatin C and microalbuminuria in patients with chronic glomerulonephritis early renal damage assessment of significance. Methods： from September 2010 to July 2013 in our hospital, 86 patients with chronic glomerulonephritis, set the observation group. Select another examination in our hospital over the same period by age, sex and other data matched 66 healthy subjects as controls. Respectively, as well as the patient＇s CysC mALB content were measured, and statistically analysis. Results： The study group and the control group Cys C levels were （2.68± 1.19） mg/L, （0.83± 1.04） mg/L, the observation group was significantly higher compared with the control group; mALB content of the observation group （38.16± 4.25） mg/L, compared to the control group （6.87± 3.93） mg/L significantly increased; Cys C and mALB positive indicators detection rate was 75.58%, 76.74%, while the Cys C and mALB joint detection, prosecution the rate was 91.86%, compared to the single index detection rate has improved significantly. Difference was statistically significant （P〈0.05）. Through the two patients with chronic glomerulonephritis indicators correlation analysis found that serum Cys C and urine mALB levels showed a significant positive correlation （r=0.941, P〈0.05）. Conclusions： The combination of CysC with mALB to detect chronic glomerulonephritis patients with early renal damage assessment, the detection rate and sensitivity were significantly higher than the index detection.