非静脉曲张上消化道出血不同剂量奥美拉唑治疗的疗效比较

目的:比较不同剂量奥美拉唑治疗非静脉曲张上消化道出血的疗效。方法:选取2012年1月至2013年8月已被收治的符合标准的病例共256例非静脉曲张上消化道出血患者随机按知情同意原则分为治疗组(128例)和对照组(128例)两组,治疗组给予大剂量奥美拉唑治疗,对照组给予常规剂量奥美拉唑治疗,比较两组患者的临床疗效并记录分析两组患者治疗前后各观察指标有无统计学差异,并于治疗72小时后评估两组患者的胃内pH值及不良反应发生情况。结果:治疗组临床疗效优于对照组(P0.05),但是各指标改善情况、胃内Ph值及不良反应发生情况与对照组相近(P0.05)。结论:大剂量奥美拉唑治疗非静脉曲张上消化道出血有良好的临床疗效。

The Comparative Study of Different Dose Omeprazole in the Treatment ofNon Varicose Upper Gastrointestinal Hemorrhage

Objective： To compare the curative effect of different dose omeprazole in the treatment of non varicose upper gastroin- testinal hemorrhage. Methods： 256 cases of diagnosed non varicose upper gastrointestinal hemorrhage who have been in our hospital were chosen from January 2012 to August 2013, dived into treatment group （128 cases） and control group （128 cases） according to in- formed consent principle randomly, large dose omeprazole were given to treat the treatment group, while normal dose omeprazole were given to treat the control group, compared the curative effect and record and analyse the observe indexes of two groups, and evaluated the gastric pH and adverse reaction of each group. Results： The clinical effect of treatment group was better than control group （P〈0.05）, but the improvement of each index and gastric pH and adverse reaction were nearly to control group （P〉0.05）. Conclusions： Large dose omeprazole has good clinical effects in treating non varicose upper gastrointestinal hemorrhage.