去甲肾上腺素转运体的研究进展

随着分子克隆技术的发展和应用,已经可以克隆出人的去甲肾上腺素转运体(Norepinephrine transporter,NET)基因转染进哺乳动物细胞内进行体外研究。去甲肾上腺素转运体在神经传递中有着非常重要的作用,许多神经以及精神系统方面的疾病,心血管疾病等都与去甲肾上腺素转运体的功能缺失或紊乱有关。本文主要介绍了去甲肾上腺素转运体的基本概念和近年来国外对去甲肾上腺素转运体的研究概况,综述了与该转运体相关的药物的研究进展以及由于去甲肾上腺素转运体的功能紊乱或丧失而导致的疾病的临床研究。最近几年对于NET基因表达调控以及各种临床疾病的研究对这些疾病的治疗方法的探索有着非常重要的意义。

Advancement on Norepinephrine Transporter*

As the development and application of molecular cloning technology, human norepinephrine transporter (NET) gene can be cloned and transfected into mammalian cells to research . Norepinephrine transporter has a very important role in the neurotransmitter.And many neurological and psychiatric diseases, cardiovascular diseases and other diseases are related to norepinephrine transporter dysfunction or disorder.This article mainly introduced norepinephrine transporter and the study of NET abroad in recent years, and summarized the research of drugs related to NET, and the clinic research of diseases as a result of norepinephrine transporter dysfunction or disorder. The research about NET in recent years have very important significance in the exploration of the treatment for these clinical disease.