老年原发性高血压患者血压晨峰与早期肾损害的临床观察

目的:探讨老年原发性高血压患者血压晨峰与早期肾损害的关系。方法:选择我院收治的94例老年原发性高血压患者进行24小时动态血压监测,并根据监测结果,将患者分为晨峰组62例和非晨峰组32例,检测和比较两组的血肌酐和尿素氮、12小时尿微量蛋白、尿β2微球蛋白、空腹血糖、血脂等指标。结果:老年高血压患者晨峰组12小时尿微量蛋白、尿β2微球蛋白均显著高于非晨峰组(P0.05);晨峰血压与12小时尿微量白蛋白(r=0.374)、尿β2微球蛋白(r=0.456)呈显著正相关。结论:老年原发性高血压患者血压晨峰与早期肾损害有关,治疗高血压的同时重视控制晨峰血压有重要意义。

Clinical Observation on the elderly hypertensive patients with morning blood pressure peak and early renal damage

Objective： To investigate the relationship between blood pressure morning peak and early kidney damage of elderly hypertensive patients. Methods： 94 elderly patients with essential hypertension were selected and 24-hour ambulatory blood pressure monitoring were detected. According to monitoring results, the patients were divided into morning peak group （62 cases） and non-MBPS group （32 cases）, the serum creatinine and blood urea nitrogen, 12-hour urine protein, urine beta 2-microglobulin, fasting blood glucose, blood lipids and other indicators of detection were tested and compared between two groups. Results： The 12-hour urine protein, urinary beta2-microglobulin of morning peak group were both significantly higher than those of the non-MBPS group （P〈0.05）; morning peak blood pressure and 12-hour urinary albumin （r=0.374）, urinary beta2-microglobulin （r=0.456） showed a significant positive correlation. Conclusion： The morning blood pressure peak of elderly patients with essential hypertension was correlated with early renal injury, morn- ing peak blood pressure control was also important as the treatment of hypertension.