| Eph-Ephrin双向信号转导途径在眼部血管新生中的作用 |
| |
| 引用本文： | 周婷,贾素洁,江俊麟.Eph-Ephrin双向信号转导途径在眼部血管新生中的作用[J].现代生物医学进展,2014,14(17):3365-3368. |
| |
| 作者姓名： | 周婷 贾素洁 江俊麟 |
| |
| 作者单位： | [1]中南大学药学院药理学系,湖南长沙410078 [2]中南大学湘雅三医院药剂科,湖南长沙410013 |
| |
| 基金项目： | 国家自然科学基金项目（81373408） |
| |
| 摘 要： | Eph/Ephrin家族是受体酪氨酸激酶家族中的最大亚族,在生理和病理性血管形成中起重要作用。眼部血管生成是糖尿病视网膜病、早产儿视网膜等眼部疾病致盲的重要因素,Eph和Ephrin基因在上述眼部疾病中有不同程度表达改变。Eph受体及其配体Ephrin之间的双向信号机制是Eph-Ephrin发挥功能的主要方式。本文就Eph-Ephrin双向信号机制在眼部血管新生中的作用进行综述。
|
| 关 键 词： | Eph受体 Ephrin配体 血管新生 |
Bidirectional Signaling Mechanismof Eph-Ephrin
in Ocular Angiogenesis* |
| |
| ZHOU Ting,JIA Su-jie,JIANG Jun-lin.Bidirectional Signaling Mechanismof Eph-Ephrin
in Ocular Angiogenesis*[J].Progress in Modern Biomedicine,2014,14(17):3365-3368. |
| |
| Authors: | ZHOU Ting JIA Su-jie JIANG Jun-lin |
| |
| Institution: | 1 Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha, Hunan, 410078, China, 2 Department of Pharmaceutics, The Third XiangYa Hospital, Central South University, Changsha, Hunan, 410013, China) |
| |
| Abstract: | Eph/Ephrin, the largest subfamily of receptor tyrosine kinases （RTKs）, plays an important role in both physiological and pathological angiogenesis. Ocular angiogenesis is an important pathological phenomenon of some ocular disorders such as diabetic retinopathy and retinopathy of prematurity, which may result in blindness. It has been reported that there are alteration of Eph and Ephrin expression in ocular angiogenesis-related disorders, suggesting that Eph-Ephrin maybe play roles in ocular angiogenesis. Eph-Ephrin exerts their roles by the bidirectional signaling between Eph receptor and Ephrin ligand. This review focused on the roles of bidirectional signaling of Eph-Ephrin in ocular angiogenesis. |
| |
| Keywords: | Eph receptor Ephrin ligand Angiogenesis |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 |
| 点击此处可从《现代生物医学进展》下载免费的PDF全文 |
|
