局灶性皮质发育不良的MRI表现及生活质量水平的评估

目的:探讨局灶性皮质发育不良(FCD)与影像学改变的相关性,并应用日常生活能力量表(ADL)评价FCD患者手术前后的生活质量改善以及癫痫缓解率。方法:回顾性分析60例FCD癫痫患者MRI检查,观察病变部位影像学变化;回顾60例FCD癫痫患者手术前后所填写的生活质量量表,分析患者总体健康水平,总体生命质量,情绪健康,日常精力,认知能力,对药物副作用的担忧,对癫痫发作的担忧,以及社会功能的变化。结果:60例FCD患者有23例(阳性率为38.3%)表现出FCD的病理特征。这23例中表现有四种:灰白质交接模糊,皮层增厚,异常脑沟脑回图案,脑叶萎缩。生活质量量表显示FCD患者(术前)生活质量明显差于正常人群,FCD患者术后的生活质量比术前得到改善。结论:FCD患者的MRI表现呈现多样性,但主要有四种类型。FCD患者术后生活质量得到改善,提示癫痫缓解率提高。

Evaluation of Focal Cortical Dysplasia MRI Performance and Quality of Life

Objective： To analyze the magnetic resonance imaging （MRI） findings of focal cortical dysplasia （FCD）, and to investigate the life quality of FCD patients. Methods： 60 patients with pathological confirmed FCD were collected in the current study to evaluate the lesion location by MRI and to assess life quality through activity of daily living scale （ADL）. Results： 23 out of 60 patients were identified to be abnormal by MRI, with the appearance of abnormal gray/white matter junction, cortex thickness, morphology of gyri and sulci, and lobar atropy. In addition, the life quality of FCD patients was improved after surgical intervention. Conclusion： FCD patients present multifarious MRI appearance. After surgical intervention, seizure remission rate was improved.