胆管癌组织中SNCG的表达及其临床意义(英文)

目的:观察γ-synuclein(SNCG)在胆管癌和正常胆管组织中的表达,并探讨其在胆管癌发生、发展中的临床意义。方法:采用免疫组化方法检测SNCG蛋白在72例胆管癌组织及41例胆管正常组织中的表达水平,并分析其与胆管癌临床病理特征的关系。结果:SNCG蛋白在胆管癌组织中的阳性表达率为73.61%(53/72),高于其在胆管正常组织中的阳性表达率(4.88%,2/41),其差异有统计学意义(P0.01)。SNCG蛋白的表达与肿瘤的淋巴结转移相关(P0.01),但与患者的年龄、性别及肿瘤分化程度无关(P0.05)。结论:SNCG蛋白的表达与胆管癌的发生、发展正相关,并对胆管癌的浸润转移发挥重要的促进作用。对SNCG蛋白的研究将可能为胆管癌的早期诊断提供新的肿瘤标志物,并为胆管癌的预后判断和诊治提供重要理论依据。

Expression and Clinical Significance of SNCG in theCholangiocarcinoma Tissues

Objective： To investigate the expression of the γ-synuclein （SNCG） in the cholangiocarcinoma and normal bile ducts tissues, and explore the role and its clinical significance of SNCG in the occurrence, development, invasion and metastasis of the cholangiocarcinoma. Methods： lmmunohistoehemical staining was used to detect the expression of SNCG protein among the 72 cases of cholangiocarcinoma and 41 cases of normal bile duct tissues. Its relationship with the clinicopathological features of the cholangioc- arcinoma was analyzed. Results： The expression positive rate of SNCG in the carcinoma of bile duct tissues was 73.61% （53/72）, which was higher than that in normal bile duct tissues （4.88%, 2/41）, and the difference was statistically significant （P〈0.01）. The expression of SNCG protein was correlated with the depth of tumor invasion and lymph node metastasis （P〈0.01）, but it had not the relationship with the age, sex of patients and the degree of tumor differentiation （P〉0.05）. Conclusions： The expression of SNCG protein was correlated with the occurrence, development, invasion and metastasis of the cholangiocarcinoma, and may play an important role in the invasion and metastasis of the carcinoma of bile duct. SNCG is expected to become a new tumor marker of the cholangiocarcinoma and provides the basis for its prognosis and developing appropriate treatment programs.