托吡酯与苯巴比妥对小儿癫痫患儿发作次数及痫样放电的影响对比

目的:研究托吡酯(topiramate,TPM)与苯巴比妥(phenobarbital,PB)对小儿癫痫(Epilepsy)患儿发作次数及痫样放电的影响。方法:将我院2010年8月至2013年8月入院接受诊治的200例癫痫患儿作为观察对象,随机分成两组。观察组采用TPM治疗,对照组采用PB治疗。对比两组患儿治疗前以及治疗后3个月癫痫发作次数、疗效以及不良反应情况。结果:观察组部分性发作减少次数、全身性发作减少次数及总发作减少次数,均显著高于对照组;观察组治愈率、愈显率、总有效率,均显著高于对照组;观察组不良反应情况显著少于对照组;差异均具有统计学意义(均P0.05)。结论:与PB相比,TPM治疗小儿癫痫疗效更佳,且不良反应更少,值得临床推荐。

Impact Comparison of Topiramate and Phenobarbital for Seizure Frequency and EpileptiformDischarges in Children with Epilepsy

Objective： To study impact comparison of topiramate and phenobarbital for seizure frequency and epileptiform dis- charges in children with epilepsy. Method： The total of 200 cases children with epilepsy in our hospital from Aug 2010 to Aug 2013 were randomly divided into two groups. The observation group was treated with TPM and the control group with PB, compared the seizure fie- quency, efficacy and adverse reactions of two groups. Results： The reduce number of partial seizures, generalized seizures and total seizures of observation group were significantly higher than those of the control group. The rate of cure, markedly effective, total efficien- cy of observation group were significantly higher than those of the control group. The adverse reactions of observation group were signif- icantly lower than that of the control group. The differences were statistically significant （P〈0.05）. Conclusion： Compared with PB, TPM shows better effect on epilepsy with less adverse reactions. It is worthy of recommendation.