硫化铜纳米粒子应用于肿瘤诊断和治疗的研究进展

癌症是当今威胁人类健康的主要疾病之一。近年来提出的近红外光介导的光热治疗,能够对肿瘤组织进行定点清除并且对正常组织具有较低的毒副作用,为肿瘤的治疗提供了新的方法。开发具有良好生物相容性的高效光热偶联剂是发展光热治疗的首要条件。随着纳米技术的飞速发展,一些金属纳米结构由于具有独特的光学特性作为光热偶联剂被广泛应用到肿瘤的光热治疗中。然而,成本高昂、制备过程繁琐以及光热稳定性较差等不足,限制了这些纳米材料的进一步应用。最新报道的新型光热偶联剂半导体硫化铜纳米粒子(copper sulfide nanoparticles,CuS NPs),由于其具有制备工艺简单、成本低廉、突出的光热稳定性和良好的生物相容性等优势,成为了当今纳米医学领域研究的热点。本文主要综述了CuS纳米粒子在肿瘤光热治疗和影像诊断方面的应用研究,并对CuS纳米粒子在生物医学领域应用中存在的问题和未来的研究方向进行了展望。

The Advances of Copper Sulfide Nanoparticles for Cancer Diagnosisand Therapy*

Cancer is a serious disease that threatens human health. Recent years, near-infrared （NIR） laser-induced phototherm- al ablation （PTA） therapy which can localize elimination of tumor cells without affiecting healthy tissues, provides a new idea for cancer therapy. To gain access to biocompatible and efficient photothermal coupling agents is the prerequisite for the development of the NIR laser-induced PTA. With the rapid development of nanotechnology, many metal nanostructures have been widely used in PTA as photothermal coupling agents due to their outstanding optical property. The semiconductor copper sulfide is a latest promising photother- mal coupling agent and has gained great interest in the nanomedicine areas due to its low cost, easy preparation, low cytotoxicity and stable optical property. The latest advances on the applications of CuS NPs in photothermal ablation and imaging diagnosis for cancer are reviewed in this paper. Moreover, the main issues existing in the biological applications are discussed.