Regulation of Drosophila TRPC channels by lipid messengers |
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Authors: | Padinjat Raghu Roger C. Hardie |
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Affiliation: | aInositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;bCambridge University Department of Physiology, Development and Neuroscience, Downing St, Cambridge CB2 3DY, United Kingdom |
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Abstract: | The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in vivo models for TRPC channel activation and has served as a paradigm for understanding TRPC function. TRP and TRPL are activated by G-protein coupled PIP2 hydrolysis through a mechanism in which IP3 receptor mediated calcium release seems dispensable. Recent analysis has provided compelling evidence that one or more PIP2 generated lipid messengers, as well as PIP2 itself, are essential for regulating TRP and TRPL activity. Evidence on the role of these lipid elements in regulating TRP and TRPL activity is discussed in this review. |
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Keywords: | Diacylglycerol kinase PIP2 PLC Calcium Degeneration |
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