The structure of the Plasmodium falciparum EBA175 ligand domain and the molecular basis of host specificity |
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| Authors: | Chattopadhyay Debasish Rayner Julian McHenry Amy M Adams John H |
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| Institution: | Division of Geographic Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA. |
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| Abstract: | Erythrocyte-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligands; the recently solved crystal structure of EBA175 reveals that terminal sialic acids on the erythrocyte glycoprotein glycophorin A are a crucial factor for erythrocyte recognition by EBA175 because they lock into pockets on its surface. Comparison with Plasmodium reichenowi EBA175 indicates that these interactions have a pivotal role in the host-specific adaptations of parasite ligands. |
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