Zika virus NS1, a pathogenicity factor with many faces |
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| Authors: | Rolf Hilgenfeld |
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| Affiliation: | 1. Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany;2. German Center for Infection Research (DZIF), Hamburg‐Lübeck‐Borstel‐Riems Site, University of Lübeck, Lübeck, Germany |
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| Abstract: | Recent publications in The EMBO Journal (Xu et al, 2016 ) and in Nature Structural & Molecular Biology (Brown et al, 2016 ) report crystal structures of the Zika virus (ZIKV) NS1 protein. The structures reveal unique surface properties that help explain the specificity of anti‐ZIKV NS1 antibodies. Possible functions of this multifaceted pathogenicity factor are discussed here on the basis of the structures and cautious extrapolation from other flaviviruses. |
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