DNA binding to SMC ATPases—trapped for release |
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| Authors: | Herwig Schüler Camilla Sjögren |
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| Institution: | 1. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden;2. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden |
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| Abstract: | The SMC/Rad50/RecN proteins are universal DNA‐associated ABC‐type ATPases with crucial functions in genome maintenance. New insights into Rad50–DNA complex structure and cohesin regulation inspire a speculative look at the entire superfamily. Identification of a continuous DNA binding site across the Rad50 dimer interface (Liu et al, 2016 ; Seifert et al, 2016 ) suggests a similar site in cohesin. The localization of this site hints a DNA‐activated mechanism for cohesin removal from chromosomes. |
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