FUScinating insights into motor neuron degeneration |
| |
| Authors: | Dorothee Dormann |
| |
| Affiliation: | 1. BioMedical Center (BMC), Ludwig‐Maximilians‐Universit?t München, Planegg‐Martinsried, Germany;2. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany;3. Graduate School of Systemic Neurosciences (GSN), Planegg‐Martinsried, Germany |
| |
| Abstract: | Point mutations in FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease—but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of The EMBO Journal, Scekic‐Zahirovic et al ( 2016 ) report that mutant FUS, but not the complete loss of FUS, triggers motor neuron degeneration in mice, arguing for a toxic gain‐of‐function mechanism. |
| |
| Keywords: | |
|
|
