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Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children
Authors:Matthias Bieg  Zuguang Gu  Dieter Weichenhan  Jan‐Philipp Mallm  Stefan Röder  Gunda Herberth  Eiko Takada  Oliver Mücke  Marcus Winter  Kristin M Junge  Konrad Grützmann  Ulrike Rolle‐Kampczyk  Qi Wang  Christian Lawerenz  Michael Borte  Tobias Polte  Matthias Schlesner  Michaela Schanne  Stefan Wiemann  Christina Geörg  Hendrik G Stunnenberg  Christoph Plass  Karsten Rippe  Junichiro Mizuguchi  Irina Lehmann
Institution:1. Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany;2. Heidelberg Center for Personalized Oncology, DKFZ‐HIPO, DKFZ, Heidelberg, Germany;3. Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany;4. Research Group Genome Organization & Function, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany;5. Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig ‐ UFZ, Leipzig, Germany;6. Department of Immunology, Tokyo Medical University, Tokyo, Japan;7. Department Metabolomics, Helmholtz Centre for Environmental Research Leipzig ‐ UFZ, Leipzig, Germany;8. Municipal Hospital “St Georg” Children's Hospital, Leipzig, Germany;9. Department of Dermatology, Venerology and Allerology, Leipzig University Medical Center, Leipzig, Germany;10. Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany;11. Sample Processing Lab, National Center for Tumor Disease and German Cancer Research Center (DKFZ), Heidelberg, Germany;12. Department of Molecular Biology, Faculty of Science, Radboud University, Nijmegen, The Netherlands
Abstract:
Keywords:environment  epigenetics     WGBS     histone modifications  enhancer deregulation
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