A new approach to toxin neutralization in Staphylococcus aureus therapy |
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Authors: | Dane Parker Alice Prince |
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Institution: | Department of Pediatrics, Columbia University, New York, NY, USA |
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Abstract: | Staphylococcus aureus is a significant human pathogen responsible for a range of diseases including pneumonia, sepsis, skin, and soft tissue infections. An important component of its success as a human pathogen is the production of a large array of virulence factors including several toxins. In this issue of EMBO Reports, Reyes‐Robles and colleagues 1 identify a glycine‐rich motif shared by bicomponent leukocidins. When this motif is deleted, the altered toxin exerts dominant‐negative effects that neutralize leukocidin function and thus represents a potentially novel avenue for S. aureus therapy. |
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