CRISPR-Cas: To Take Up DNA or Not-That Is the Question |
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| Authors: | Ariel D Weinberger Michael S Gilmore |
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| Affiliation: | Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | Landmark experiments in the 1920s showed that capsule switching is critical for Streptococcus pneumonia survival. Further studies demonstrated that capsule "transformation" occurs via DNA uptake. In this issue of Cell Host and Microbe, Bikard et?al. (2012) show that CRISPR-Cas systems inhibit DNA uptake, selecting for the outgrowth of CRISPR-defective pneumococci. |
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