D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation |
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| Authors: | Tao Zhang Li-Hui Lu Hao Liu Jun-Wei Wang Rui-Xue Wang Yun-Xiao Zhang Jing-Chao Tao |
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| Affiliation: | College of Chemistry and Molecular Engineering, New Drug Research & Development Center, Zhengzhou University, 75 Daxue Road, Zhengzhou 450052, PR China. |
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| Abstract: | A series of polyhydric, amino alcohol and tricyclic derivatives were facilely synthesized by D-ring modification of isosteviol. These compounds were screened for their cytotoxic activities against four human tumor cell lines in vitro. Among them, the 15-α-aminomethyl-16-β-hydroxyl isosteviol 23 exhibits significant cytotoxicity superior to the positive control (cisplatin) against EC9706, PC-3 and HCT-116 cell lines. |
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