Translesion synthesis, or molecular steeplechase |
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| Authors: | G B Zavilgelsky |
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| Institution: | (1) State Research Center of Russian Federation GosNIIGenetika, 113545 Moscow, Russia |
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| Abstract: | The review is devoted to the latest achievements in studying SOS mutagenesis and translesion synthesis (DNA synthesis on damaged
templates). A group of novel DNA polymerases (proteins of the UmuC family) have been found, capable of bypassing the replication
block caused by a lethal lesion in the template. A special role of the steric factor in selection of the complementary nucleotide
at the active center of DNA polymerase is shown. |
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| Keywords: | replication DNA polymerase pyrimidine dimers AP sites SOS mutagenesis umuC umuD xeroderma pigmentosum translesion synthesis |
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