Ubiquitin in chains |
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| Authors: | Pickart C M |
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| Affiliation: | Dept of Biochemistry and Molecular Biology, School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. cpickart@welchlink.welch.jhu.edu |
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| Abstract: | The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation. Recent results have revealed important determinants of polyubiquitin-chain recognition by proteasomes, helping to explain the biological rationale behind this novel signaling mechanism. |
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