Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent |
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| Authors: | S Bhowmick R Bose M Pal S P Pal |
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| Institution: | Department of Pharmacy, Jadavpur University, Calcutta, India. |
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| Abstract: | N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats. |
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