Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen |
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| Authors: | Julia J Inglis Gabriel Criado Mino Medghalchi Melanie Andrews Ann Sandison Marc Feldmann Richard O Williams |
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| Affiliation: | (1) Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, W6 8LH London, UK;(2) Department of Histopathology, Imperial College London, Charing Cross Hospital, Fulham Palace Road, W6 8RF London, UK |
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| Abstract: | Many genetically modified mouse strains are now available on a C57BL/6 (H-2b) background, a strain that is relatively resistant to collagen-induced arthritis. To facilitate the molecular understanding of autoimmune arthritis, we characterised the induction of arthritis in C57BL/6 mice and then validated the disease as a relevant pre-clinical model for rheumatoid arthritis. |
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