A novel superfamily of enzymes that catalyze the modification of guanidino groups |
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| Authors: | Shirai H Blundell T L Mizuguchi K |
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| Affiliation: | Dept of Biochemistry, University of Cambridge, Old Addenbrookes Site, 80 Tennis Court Road, CB2 1GA, Cambridge, UK. |
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| Abstract: | Three enzymes, peptidyl-arginine deiminase from Porphyromonas gingivalis, arginine deiminase and amidinotransferase are traditionally classified separately. By combining PSI-BLAST and FUGUE, data presented in this article describe how these enzymes belong to a novel superfamily, adopting a common fold and sharing similar catalytic mechanisms. |
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