The presence of 3-hydroxy oxylipins in pathogenic microbes |
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Authors: | Sebolai Olihile M Pohl Carolina H Kock Lodewyk J F Chaturvedi Vishnu del Poeta Maurizio |
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Institution: | Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, 205 Nelson Mandela Drive, Park West, Bloemfontein 9301, South Africa. sebolaiom@ufs.ac.za |
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Abstract: | There is a sufficient body of work documenting the distribution of 3-hydroxy oxylipins in microbes. However, there is limited information on the role of these compounds in microbial pathogenesis. When derived from mammalian cells, these compounds regulate patho-biological processes, thus an understanding of 3-hydroxy oxylipin function and metabolism could prove important in shedding light on how these compounds mediate cellular pathology and physiology. This could present 3-hydroxy oxylipin biosynthetic pathways as targets for drug development. In this minireview, we interrogate the relevant yeast and bacterial 3-hydroxy oxylipin literature in order to appreciate how these compounds may influence the inflammatory response leading to disease development. |
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