Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system |
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Authors: | Yazid Samia Norling Lucy V Flower Rod J |
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Institution: | Centre for Biochemical Pharmacology, The William Harvey Research Institute, St Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK. |
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Abstract: | The action of anti-inflammatory and anti-allergic drugs on the eicosanoid system is briefly reviewed. In addition to the aspirin-like drugs, which directly inhibit the cyclo-oxygenase enzymes, other drugs such as the glucocorticoids and the cromones also inhibit the formation of eicosanoids. In the latter cases this is bought about through the release of a protein factor that acts through formyl peptide receptors on the target cell surface. Of growing interest, is the observation that this receptor is also a target for other eicosanoids, such as lipoxins and resolvins that modulate host defence systems. |
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