Polymorphism of the <Emphasis Type="Italic">CD36</Emphasis> Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age |
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Authors: | Monika Ewa Ra? Janina Suchy Grzegorz Kurzawski Agnieszka Kurlapska Krzysztof Safranow Micha? Ra? Dagmara Sagasz-Tysiewicz Andrzej Krzystolik Wojciech Poncyljusz Katarzyna Jakubowska Maria Olszewska Beata Krupa Dariusz Chlubek |
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Institution: | Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. carmon12@gmail.com |
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Abstract: | This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The study group consisted of 90 patients; the men were ≤ 50 years old and the women were ≤ 55 years old. Amplicons of exons 4 and 5 including fragments of introns were analyzed by DHPLC. Two polymorphisms were found: IVS3-6 T/C (rs3173798) and IVS4-10 G/A (rs3211892). The C allele of the IVS3-6 T/C polymorphism was associated with higher prevalence of obesity and diabetes, higher hsCRP, lower Lp(a) serum concentrations, and younger age at myocardial infarction. The A allele of the IVS4-10 G/A polymorphism was associated with older age of myocardial infarction and higher white blood cell count. The functional role of CD36 polymorphisms in CAD development needs further research. |
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