Linear sesterterpenes from the Caribbean sponge Thorecta horridus with inflammatory activity

Two new linear sesterterpenes 1 and 2, containing an α,β-unsaturated γ-lactone ring, have been isolated from the Caribbean sponge Thorecta horridus, Hyatt 1877 (F. Thorectidae). The structures of the two new metabolites were established on the basis of spectral data including 2D NMR experiments. Compound 1 exhibits inflammatory activity.Structures of two new linear sesterterpenes 1 and 2 from the sponge Thorecta horridus, determined through HREIMS, 1D and 2D NMR experiments, are reported. Compound 1 exhibits inflammatory activity.