Differential sensitivity of hypothalamic and medullary opiocortin and tyrosine hydroxylase neurons to the neurotoxic effects of monosodium glutamate (MSG) |
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| Authors: | W H Pilcher S A Joseph |
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| Institution: | 1. The Neuroendocrine Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 USA;2. Department of Neurosurgery, University of Rochester School of medicine and Dentistry, Rochester, NY 14642 USA;1. Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;2. Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Jieyang 515200, China;3. College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China;4. School of Materials Science and Engineering, Dongguan University of Technology, Dongguan 523808, China;1. School of Materials Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mallick Road, Jadavpur, Kolkata 700032, India;2. Institute of Nano Science and Technology, Sector-81, Mohali 140306, Punjab, India;3. School of Physical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mallick Road, Jadavpur, Kolkata 700032, India;4. Department of Chemistry, University of Kalyani, Kalyani 741235, India;5. UGC-DAE Consortium for Scientific Research, University Campus, Khandwa Road, Indore 452001, India;1. Department of Economics and Finance, BITS Pilani KK Birla Goa Campus, India;2. School of Accountancy & PwC/Joseph A. Silvoso Distinguished Professor, University of Missouri, Columbia, USA;3. Department of Business Administration, Oregon State University-Cascades, 1500 SW Chandler Avenue, Bend, OR, 97702, USA;1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People''s Republic of China;2. Shanghai Institute of Precision Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, People''s Republic of China;3. Shanghai Jieshi Medical Technology Co., Ltd., Shanghai 200120, People''s Republic of China |
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| Abstract: | The distribution of opiocortin- (OP-ir) and tyrosine hydroxylase-immunoreactive (TH-ir) perikarya was examined immunocytochemically in rats treated neonatally with the neurotoxin monosodium glutamate (MSG). While OP-ir and TH-ir perikarya were eliminated in the arcuate nucleus in treated animals, the OP-ir and TH-ir cell groups of the nucleus tractus solitarius and contiguous medullary regions were unaffected. This selective elimination of arcuate neurons permitted us to examine specifically the fiber projections of the medullary OP-ir perikarya in treated animals. This revealed a preferential distribution of delicate fibers originating in NTS, to discrete medullary and pontine areas. In control animals, these same terminal fields appeared to be more densely populated with an additional population of thicker OP-ir fibers, suggesting the possibility of a shared innervation of these brainstem regions by both hypothalamic and medullary OP-ir neurons. |
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