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Design of a covalently linked human interleukin-10 fusion protein and its secretory expression in Escherichia coli |
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| Authors: | Guggenbichler Florian Büttner Carolin Rudolph Wolfram Zimmermann Kurt Gunzer Florian Pöhlmann Christoph |
| Institution: | 1.Institute of Medical Microbiology and Hygiene, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany ;2.SymbioPharm GmbH, Auf den Lüppen 8, 35745, Herborn-Hörbach, Germany ;3.Department of Medical Microbiology and Hygiene, Hospital of Memmingen, Bismarckstrasse 23, 87700, Memmingen, Germany ; |
| Abstract: | Applied Microbiology and Biotechnology - Wild-type human interleukin-10 (hIL-10) is a non-covalent homodimer with a short half-life, thus limiting its therapeutic applications in vivo. To avoid... |
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