Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45 |
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| Authors: | Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak |
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| Institution: | 1. Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.; 2. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.; 3. College of Health, Beauty Care and Education in Poznan, Faculty in Gdynia, Gdynia, Poland.; University of Tennessee, United States of America, |
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| Abstract: | Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide. |
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