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Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Affiliation:1. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA;2. Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA;3. Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA;4. MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK;5. University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK;6. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA;7. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;8. Department of Internal Medicine, Metabolic and Vascular Medicine, MedicCal Faculty Carl Gustav Carus, Dresden, Germany;9. Helmholtz Zentrum München, Paul Langerhans Institute Dresden, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany;10. German Center for Diabetes Research, Neuherberg, Germany;11. Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK;12. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK;13. Medical Faculty Mannheim, Heidelberg University, Mannheim, BW, Germany;14. University of Helsinki, Helsinki, Finland;15. Folkhälsan Research Center, Helsinki, Finland;16. Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland;17. College of Medicine and Health, Exeter University, Exeter, UK;18. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany;19. Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany;20. Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden;21. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden;22. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany;23. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;24. Department of Internal Medicine, Prevention and Care of Diabetes, Medical Faculty Carl Gustav Carus, Dresden, Germany;25. Steno Diabetes Center Odense, Odense, Denmark;26. SYNLAB MVZ Humangenetik Mannheim, Mannheim, BW, Germany;27. Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK;28. Nuffield Department of Population Health, University of Oxford, Oxford, UK;29. Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK;30. Broad Institute, Cambridge, MA, USA;31. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA;32. Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland;33. Institute of Nutritional Sciences, Friedrich-Schiller-University, Jena, Germany;34. Competence Cluster for Nutrition and Cardiovascular Health, Halle-Jena-Leipzig, Germany;35. Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK;36. School of Health and Wellbeing, University of Glasgow, Glasgow, UK;37. Chair of Food Chemistry and Molecular Sensory Science, Technische Universität München, Freising, Germany;38. Department of Medicine Solna, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden;39. Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK;40. Institute of Health and Wellbeing, Mental Health and Wellbeing, University of Glasgow, Glasgow, UK;41. Abdominal Center, Endocrinology, Helsinki University Hospital, Helsinki, Finland;42. Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK;43. Department of Geriatrics, Uppsala University, Uppsala, Sweden;44. Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy;45. Cardiovascular Prevention Area, Centro Cardiologico Monzino I.R.C.C.S., Milan, Italy;46. Department of General Practice and Primary Health Care, Faculty of Medicine, University of Helsinki, Helsinki, Finland;47. Folkhälsan Research Centre, Helsinki, Finland;48. Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore;49. Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA;50. Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA;51. Department of Medicine, Harvard Medical School, Boston, MA, USA;52. Department of Internal Medicine, Diabetology, Tübingen, Germany;53. Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany;54. Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland;55. PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;56. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;57. Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;58. Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim, BW, Germany;59. Department of Medicine, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA;60. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA;61. Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK;62. Health Data Research UK, Gibbs Building, London, UK;63. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK;64. Exeter Centre of Excellence for Diabetes Research, Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK;65. MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK;66. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;67. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA;68. Computational Medicine, Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany;69. Precision Healthcare University Research Institute, Queen Mary University of London, London, UK
Abstract:
Keywords:GWAS  proinsulin  meta-analysis  type 2 diabetes  colocalization  eQTL  enhancer  conditional  signal  fine-mapping
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