|
|||||
|
|
Gene Copy-Number Variation in Haploid and Diploid Strains of the Yeast Saccharomyces cerevisiae |
|
| Authors: | Hengshan Zhang Ane F B Zeidler Wei Song Christopher M Puccia Ewa Malc Patricia W Greenwell Piotr A Mieczkowski Thomas D Petes Juan Lucas Argueso |
| Institution: | *Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710;†Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, and;‡Lineberger Comprehensive Cancer Center, Carolina Center for Genome Science, Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 |
| Abstract: | The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast. |
| Keywords: | copy-number variation nonallelic homologous recombination gene amplification chromosomal rearrangements |