Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability |
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| Affiliation: | 1. School of Medicine, Nantong University, Nantong 226001, China;2. School of Pharmacy, Nantong University, Nantong 226001, China;3. Department of Neurochemistry, Institute for Nautical Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, China;1. Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran;2. Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, HU3 2JZ, UK;4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;5. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. College of Medicine, Hubei University for Nationalities, Enshi, 445000, China;2. Tianjiu Research and Development Center for Exercise Nutrition and Foods, College of Health Science, Wuhan Sports University, Wuhan, 430079, China;3. Key Laboratory of Biological Resource Prevention and Utilization of Hubei Province, Enshi, 445000, China;1. Department of Pharmacology, Medical Research Division, The National Research Centre, 33 EL Bohouth St. (former EL Tahrir St.), P.O. 12622, Dokki, Giza, Egypt;2. Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Ahram Canadian University, Egypt;3. Clinical Biochemistry Unit, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt;4. Department of Pathology, Faculty of Medicine, Helwan University, Egypt;5. Instructor of Pathology, October University of Modern Sciences and Arts (MSA) University, Egypt |
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| Abstract: | As an important factor leading to aging and chronic diseases, oxidative stress has become a hot research topic. Trehalose is a natural sugar widely found in many edible plants, animals and natural microorganisms, and recent studies have suggested that trehalose is an antioxidant, although its underlying molecular mechanism is unclear. Therefore, we evaluated the protective mechanism of trehalose against oxidative stress-induced senescence. In the mouse model of d-galactose (D-gal) induced aging, we found that trehalose significantly reversed the learning and memory impairment caused by D-gal and improved the ability to explore unknown things, which was associated with a significant reduction in brain tissue damage. Further studies have shown that trehalose activates the expressions of downstream target genes HO-1, NQO1, SOD, GSH and CAT by promoting the nuclear translocation of Nrf2 in the liver. The detoxification ability of organs is increased, antioxidant enzyme activity is enhanced, lipid peroxidation is reduced, and the secretion of inflammatory factors TNF-α, IL-1β, il-6 is decreased. In conclusion, trehalose play an anti-aging role by activating genes related to Nrf2 pathway. |
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| Keywords: | Trehalose Nrf2 Antioxidant stress Cognitive impairment Inflammation |
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